[Effects of HPA and NF-E2 related factor on smoking related laryngeal squamous cell carcinoma].

Objective:To further explore the prognostic effects of Heparanase(HPA) and NF-E2 related factor (NRF2) on smoking related laryngeal squamous cell carcinoma,we detect the expression of HPA and NRF2 on smoking related laryngeal squamous cell carcinoma patients.Method:Continuously collected 84 patients with laryngeal squamous cell carcinoma in the Ningde Hospital from 2014 to 2015.All patients were divided into three groups according to smoking index:group A (severe smoking patients with laryngeal carcinoma 30 cases),group B(mild to moderate smokers 20 cases) and group C (no smoking in laryngeal carcinoma patients with 34 cases).Antioxidative indices in serum and the expression of HPA and NRF2 in three groups of patients were detected, and to explore their relationship with prognosis and clinical staging of patients.Result:The HPA and NRF2 were highly expressed in the cancer tissues of patients with stage Ⅲ-Ⅳ,while the expression of HPA and NRF2 in patients with stage Ⅰ-Ⅱ was low. The expression level of NRF2 in group A was significantly higher than that of group Band group C(P <0.05) as well as the NRF2 expression levels in higher stage patients with laryngeal cancer were higher than those of low stages.The expression of HPA and NRF2 is related to the pathological stage in laryngeal squamous cell carcinoma patients(P <0.05).Conclusion:Compared with non smoking patients, severe smoking patients with laryngeal cancer will face more severe oxidative stress. The expression of HPA and NRF2 in laryngeal squamous cell carcinoma patients is related to the pathological stage.

Red mud (RM)-Induced enhancement of iron plaque formation reduces arsenic and metal accumulation in two wetland plant species.

Human activities have resulted in arsenic (As) and heavy metals accumulation in paddy soils in China. Phytoremediation has been suggested as an effective and low-cost method to clean up contaminated soils. A combined soil-sand pot experiment was conducted to investigate the influence of red mud (RM) supply on iron plaque formation and As and heavy metal accumulation in two wetland plant species (Cyperus alternifolius Rottb., Echinodorus amazonicus Rataj), using As and heavy metals polluted paddy soil combined with three rates of RM application (0, 2%, 5%). The results showed that RM supply significantly decreased As and heavy metals accumulation in shoots of the two plants due to the decrease of As and heavy metal availability and the enhancement of the formation of iron plaque on the root surface and in the rhizosphere. Both wetland plants supplied with RM tended to have more Fe plaque, higher As and heavy metals on roots and in their rhizospheres, and were more tolerant of As and heavy metal toxicity. The results suggest that RM-induced enhancement of the formation of iron plaque on the root surface and in the rhizosphere of wetland plants may be significant for remediation of soils contaminated with As and heavy metals.

[Studies on the chemical constituents of Ventilago leiocarpa Benth].

Three anthraquinones (1-3) and two naphthoquinones(4,5) were isolated from the root of Ventilago leiocarpa Benth (Rhamnaceae). On the basis of spectroscopic data and X-ray diffraction analysis compound 5, ventilagolin, was shown to be a new naphthoquinone occurring as a racemate.

[Coetsoidin A, a new diterpenoid from Rabdosia coetsoides C. Y. Wu].

From the leaves of Rabdosia coetsoides C. Y. Wu, a new diterpenoid, coetsoidin A (I) was isolated and its structure was established by spectroscopic and X-ray diffraction analysis. It is the first instance of a kaurene type diterpenoid possessing alpha,beta-unsaturated ketone functionality in ring B.